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Myoclonus in Patients With Coronavirus Disease 2019: A Multicenter Case Series.

Identifieur interne : 000113 ( Main/Exploration ); précédent : 000112; suivant : 000114

Myoclonus in Patients With Coronavirus Disease 2019: A Multicenter Case Series.

Auteurs : Pria Anand [États-Unis] ; Asma Zakaria [États-Unis] ; Karima Benameur [États-Unis] ; Charlene Ong [États-Unis] ; Maryann Putman [États-Unis] ; Sarah O'Shea [États-Unis] ; David Greer [États-Unis] ; Anna M. Cervantes-Arslanian [États-Unis]

Source :

RBID : pubmed:32804787

Descripteurs français

English descriptors

Abstract

OBJECTIVES

To describe the risk factors for and outcomes after myoclonus in a cohort of patients with coronavirus disease 2019.

DESIGN

Multicenter case series.

SETTING

Three tertiary care hospitals in Massachusetts, Georgia, and Virginia.

PATIENTS

Eight patients with clinical myoclonus in the setting of coronavirus disease 2019.

INTERVENTIONS & MEASUREMENTS AND MAIN RESULTS

Outcomes in patients with myoclonus were variable, with one patient who died during the study period and five who were successfully extubated cognitively intact and without focal neurologic deficits. In five cases, the myoclonus completely resolved within 2 days of onset, while in three cases, it persisted for 10 days or longer. Seven patients experienced significant metabolic derangements, hypoxemia, or exposure to sedating medications that may have contributed to the development of myoclonus. One patient presented with encephalopathy and developed prolonged myoclonus in the absence of clear systemic provoking factors.

CONCLUSIONS

Our findings suggest that myoclonus may be observed in severe acute respiratory syndrome coronavirus 2 infected patients, even in the absence of hypoxia. This association warrants further evaluation in larger cohorts to determine whether the presence of myoclonus may aid in the assessment of disease severity, neurologic involvement, or prognostication.


DOI: 10.1097/CCM.0000000000004570
PubMed: 32804787
PubMed Central: PMC7448712


Affiliations:


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Le document en format XML

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<b>OBJECTIVES</b>
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<p>To describe the risk factors for and outcomes after myoclonus in a cohort of patients with coronavirus disease 2019.</p>
</div>
<div type="abstract" xml:lang="en">
<p>
<b>DESIGN</b>
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<p>Multicenter case series.</p>
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<p>
<b>SETTING</b>
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<b>PATIENTS</b>
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<p>Eight patients with clinical myoclonus in the setting of coronavirus disease 2019.</p>
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<div type="abstract" xml:lang="en">
<p>
<b>INTERVENTIONS & MEASUREMENTS AND MAIN RESULTS</b>
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<p>Outcomes in patients with myoclonus were variable, with one patient who died during the study period and five who were successfully extubated cognitively intact and without focal neurologic deficits. In five cases, the myoclonus completely resolved within 2 days of onset, while in three cases, it persisted for 10 days or longer. Seven patients experienced significant metabolic derangements, hypoxemia, or exposure to sedating medications that may have contributed to the development of myoclonus. One patient presented with encephalopathy and developed prolonged myoclonus in the absence of clear systemic provoking factors.</p>
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<p>Our findings suggest that myoclonus may be observed in severe acute respiratory syndrome coronavirus 2 infected patients, even in the absence of hypoxia. This association warrants further evaluation in larger cohorts to determine whether the presence of myoclonus may aid in the assessment of disease severity, neurologic involvement, or prognostication.</p>
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   |clé=     pubmed:32804787
   |texte=   Myoclonus in Patients With Coronavirus Disease 2019: A Multicenter Case Series.
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